Lipopolysaccharides (LPS) are the major cell wall component in all Gram-negative bacteria. LPS consists of two regions: polysaccharide and lipid A. Lipid A contains the endotoxic component which varies greatly from species to species. For example, the lipid A from E.coli is highly potent at activating cytokines and adhesion molecules while lipid A from P. gingivalis is not (see figure below).
Astarte Biologics offers a line of ultra purified and highly characterized LPS from various species of gram negative bacteria.
Our LPS offers many advantages over competitors:
- Highly purified - Multiple purification process to remove protein and nucleic acid contamination
- Known Structure - LPS is highly characterized by Mass Spec(MS) and GC/MS
- Known Bioactivity - Tested for activation of E-Selectin, IL-8 and TNF
Publications using LPS from Astarte Biologics
Yee M, Kim A, Alpagot T, Duzgunes. Porphyromonas gingivalis stimulates IL-18 secretion in human monocytic THP-1 cells. Microbes and Infection, 2012 14:684-689
Marsella R, Santoro D, Ahrens K. Early exposure to probiotics in a canine model of atopic dermatitis has long-term clinical and immunological effects. Veterinary Immunol and Immunopath 2012 146:185-189.
Pg 1449 m/z